Are NSAIDs the Most Effective Medicines for Knee Pain Relief

best nsaid for knee pain

From holding up the whole body weight to all twisting & turning motions, Knee makes itself the most crucial part of the body. But the complexity it poses makes it more prone to several disorders. Hence, knee pain is one of the markers of underlying disturbance in the knee structure. Therefore, knee pain relief products and medicines for knee pain like NSAIDs are the best way to overcome it. In fact, NSAIDs are regarded as the most effective non-surgical treatment for knee pain.

A Brief Overlay of Knee Pain

Knee pain can originate from any bone, ligaments, cartilages & tendons (meniscus) of the knee.
Hence, knee pain is mainly categorized into,

  • Anterior (front knee pain)
  • Medial ( Inner Knee pain )
  • lateral  (side knee pain )
  • posterior (back knee pain)

Anterior Knee Pain

Anterior knee pain mainly stems from issues in your patella, the knee cap. This includes :

Runner’s Knee (Patellofemoral Pain Syndrome)

Very common injury associated with knee cap. This happens when a knee cap comes in contact with femur & rubs against it. Hence, resulting in pain on the anterior side of the knee.

Jumper’s Knee (Patellar Tendonitis)

When patellar tendon is overused it becomes a common source for inducing pain.

Posterior Knee Pain (Back Knee Pain)

Baker’s Cyst:

A prominent, swollen cyst at the back of your knee, can be very discomforting. This condition is called as baker’s cyst or more commonly popliteal cyst. It originates from the problems with your knee joint, mainly due to knee arthritis or abrasion of cartilage

Biceps Femoris Tendonitis:

Most common overuse injury of biceps femoris causing back knee pain.

Lateral Knee Pain (Side Knee Pain)

Lateral Collateral Ligament Injury

A sudden turning & twisting motions can cause tension on your lateral collateral ligament locating outside the knee. Hence, resulting in stretching or tearing of it.

Iliotibial Band Syndrome (ITBS)

It is very common in cyclists & runners. It occurs due to the overuse of cartilages locating at the lateral side of the knee.

Lateral Meniscus Tear

One of the main causes of lateral knee pain. Moreover, it is also accompanied by stiffness, swelling & locking of your knee.

Medial Knee Pain (Inner Knee Pain)

A range of particular injuries can trigger inner knee pain. This includes :

Medial Meniscus Tear

Injury of protective cartilage lining the joint

Sprain or tear of medial collateral ligament

A ligament that runs up inside your knee joint. Injury of it can immediately result in swelling & intense inner knee pain


A small fluid-filled cavity that helps to aid friction in your bones is called the bursa. Inflammation of this bursa due to injury, arthritis or overuse of bones can cause medial knee pain.

Medial Plica

The thin folds surrounding joint lining or synovial tissue. It covers the inner part of your knee. Due to repetitive flexing & extension motion of your knee, these folds become thick. Hence, increasing more chances to get compressed in your thigh bone or between your thigh bone & knee cap.

Underlying medical conditions such as degenerative osteoarthritis, gout can also trigger knee pain.


knee pain relief

Knee pain could become a considerable obstacle in performing daily grinds. Therefore, medicaments for knee pain relief are frequently using worldwide to get rid of this discomfort as soon as possible. Doctors are prescribing medicines for knee pain relief primarily to treat underlying conditions.

Best Pain Killers for Knee Pain

People are always wondering about what is the best pain killer for knee pain in order to continue with their fast-paced life.

This mainly includes analgesics & NSAIDs. NSAIDs for knee pain, have shown significant benefits in pain reduction as well as in taming inflammation. For this reason, they rank among the most effective non-surgical treatment for knee disorders. Hence, they are extensively using worldwide in acute & as well as chronic pain management.

But as they carry potential side effects so, their consideration is extremely important. Especially in persons possessing heart & stomach problems.

NSAIDs for Knee Pain

Enlisting the best medicines for knee pain,

Naproxen for Knee Pain

A widely used NSAID for knee pain relief. Available in a variety of dosage forms.

Naproxen is selling over the counter commonly in 220mg dose. For more severe pain, doctors often prescribe high doses of it.
Recent research is made among oral acetaminophen, injections of cortisone, platelet-rich plasma (PRP) & hyaluronic acid (HA) and several traditional NSAIDs. Out of which, naproxen has the highest probability in improving joint functions. Also, it was regarded as the best NSAID for osteoarthritis.

The pain-relieving effect is comparatively longer than ibuprofen. The Doctor may prescribe stomach protectors with naproxen intended for long term treatment. The traditional COX-inhibitor is safe (at least for the short term) & yet cost-effective.

Ibuprofen for Knee Pain

Ibuprofen, another over the counter medication that knocks out knee pain. The doctor recommends taking ibuprofen for inner knee pain treatment that could arise from conditions like arthritis, sprains & strains.
Ibuprofen is beneficial for occasional use but not for frequent use. Because being non-selective COX-inhibitor it possesses potential side effects if taken daily.

Over the counter dose is 200-400mg taken up to 3 times a day after meal. However, the dose should be according to the severity of pain.

Celecoxib for knee pain

Unlike other traditional NSAIDs, celecoxib is COX-2 selective. Hence it doesn’t interfere with the clotting of blood  & stomach lining (with short term treatment).

It is the only COX-2 available in the market. Commonly under the brand name Celebrex.

Doctors often prescribe stronger NSAIDs when simple OTC doesn’t work.
Celecoxib is indeed among the most potent medicines for knee pain relief while also treating inflammation. It reduces the pain to a very manageable level.

Injection for Knee Pain Relief

Injectables are a step between oral medications & knee replacement surgery. The doctor may prescribe it in an account of severe knee pain.

NSAIDs Injections

NSAID injections are very useful in postoperative knee pain relief. They are considered as the first-line therapy medicines for knee pain relief. Hence, reducing the need for opioids. This includes powerful NSAIDs such as ketorolac marketed as tramadol.

Corticosteroids Injections

They aren’t a permanent solution. Corticosteroids reduce inflammation & relieve knee pain to a great extent.

Hyaluronic Acid Injections

They are recently approved by the FDA. Mostly recommended in patients having osteoarthritis. They replace missing joint lubricant, thereby relieving pain.

Other Knee Pain Relief Products


Acetaminophen can also be the choice of drug for mild to moderate knee pain relief. Plus, it is also easy on the stomach. However, liver toxicity can occur in high doses.
Moreover, it only works well for pain not originating from inflammation.

Pain-Relieving Gels & Creams

A good choice for pain relief when your skin irritates from counter-irritants. Creams usually involving salicylates are effective in knee pain relief Such as myoflex, sportscreme.  It is one of the widely suggested medicaments for knee pain relief.

Knee Braces

For mild to moderate chronic knee pain relief, a dual or wrap-around brace is the best choice. It provides adding support to your injured knee and supporting the movement. Usually recommended when the patella is dislocated. Hence, keeping it in the right place during walking, running & other athletic activity.

1 thought on “Are NSAIDs the Most Effective Medicines for Knee Pain Relief”

  1. Best website for NSAID information I was personally feeling ill from the pain in joints and my knees were not allowing me to do my daily work but after reading this article I have got a really great help to deal with it, thanks for it.


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