Finding the Safest Nsaid for Stomach Pain Side Effects?

Best NSAID for stomach

The invention of NSAID is undoubtedly an astounding leap in the field of medicine. These drugs have helped us in our everyday life. From a mere toothache to pain related to menstrual cramps, NSAIDs have eased our pain and increased our quality of life. However, this drug can cause mild to severe side effects. Some potential side effects are listed below:

  • Dizziness
  • Stomach ulcers
  • Allergic reactions like buccal or skin irritation
  • Stomach pain
  • Heartburn
  • Vital organ damage
  • High blood pressure

The most common side effect which causes us to fret is regarding the gastrointestinal tract. These side effects are observed only upon frequent and unadvised use of NSAIDs.

Here, we’ll discuss some of the best NSAID for the stomach. In general NSAIDs cause, GIT disturbance but some NSAIDs are termed safer for stomach pain side effects.


Ibuprofen is very common over the counter NSAID. It reduces inflammation and swelling by blocking prostaglandin. This, in turn, restricts oxygen flow. The restriction also blocks the blood supply to the vital organs causing damage to them as well. Ibuprofen can lead to various negative outcomes leaving you with some general questions. Some of them are answered below:

Can Ibuprofen Cause Ulcers?

Ibuprofen has a very gloomy effect on the stomach due to its mechanism of action. This is due to the interference and blockage in prostaglandins. They cause the thinning of the gastric mucosa. Henceforth, the walls of the stomach get damaged by the action of gastric acid. These lead to the development of very painful ulcers. Ulcers don’t form by small doses of NSAID for back pain or toothache. But mostly cause-effect when taken for a prolonged time and high doses. Even though it is a good NSAID but IBuprofen can cause ulcers and not be considered the safest NSAID for the stomach.

Ibuprofen Gastritis

Gastritis is basically the inflammation of the gastric mucosa. It is ironic how an anti-inflammatory drug can cause inflammation. But this occurs due to the interference of the stomach’s ability to protect itself from the gastric acid. NSAIDs slow down the process of formation of the mucosa as the lipid are made of certain prostaglandin. Ibuprofen gastritis, however, occurs after use for an extended time.

How to Stop Stomach Pain From Ibuprofen

There can be a number of reasons for stomachache. Usually, an NSAID is helpful for it but it can also worsen it. Ibuprofen is one of the safest NSAID for the stomach. It can reduce the pain but there are still some precautionary measures to take. It is best to have a healthcare official advise over the condition. Fortunately, some measures can prove to be beneficial when administering ibuprofen for stomach pain:

  • Do not take Ibuprofen on an empty stomach
  • Administer with an antacid or milk
  • Use along with probiotics

Treatment for Stomach Bleeding From Ibuprofen

It is a big risk to administer NSAID for gastric problems. Prolong use of NSAIDs like ibuprofen are the reason for stomach bleeding and peptic ulcers. Symptoms of stomach bleeding can be black stool, bright red blood in vomit or cramps in the abdomen. Usually, it is due to gastritis or ulcers. A dose of NSAID will only deteriorate the condition. Minor stomach bleeding usually heals on its own. It is best to consult a physician before you plan on proceeding your treatment of stomach bleeding with ibuprofen.


Naproxen is commonly available as aleve. It is one of the safest NSAID in the market. The drug has a great effect on rheumatoid arthritis and other inflammatory pain. Naproxen, like other NSAIDs, has some drawbacks to its use. It amplifies the load on the heart and also retains water. These effects can cause damage to the heart and kidney

Naproxen and Stomach Ulcers

All NSAIDs have an adverse effect on the stomach and are responsible for the deterioration of the mucosal lining. Doctors around the globe advise to take the least effective dose of the drug and to not lie down for 10 minutes after administration. This is to avoid gastric bleeding or ulcer formation. In a nutshell, do not use an NSAID for a stomach ache unless the doctor has given the green signal.


Excedrin is a combination of three drugs namely caffeine, paracetamol and aspirin. It works best for migraine and headache due to its rapid onset of action. Excedrin comes under the NSAID class due to the presence of aspirin in it. It is a potent drug and can show some side effects including nausea and vomiting.

How to Relieve Stomach From Excedrin?

Excedrin works to relieve migraines generally and can cause an upset stomach if taken on an empty stomach. Excessive use may lead to holes in the stomach and intestinal lining or even gastritis. It can surely not live up to the list of the ‘safest NSAID for stomach’.

Stomach Friendly Anti-Inflammatory Drugs.

According to a recent study, 3200-16500 patients die due to NSAIDs yearly in America. The finer way to administer an NSAID without getting an upset stomach is to ingest it after a full meal. Alcohol consumption also enhances the adverse effect of the drug.

Which Nsaid Is the Easiest on the Stomach?

NSAID for stomach pain

NSAIDs like ibuprofen and naproxen are more stomach-friendly anti-inflammatory drugs and are some of the best NSAID for stomach and are easy on the stomach than the other more potent NSAIDs.

NSAID Alternative

Healthcare officials strictly prohibit the use of NSAIDs in GI complications. Nevertheless, it is vital to remember that NSAID abuse or overdose can have very serious outcomes.

  • One of the best NSAID alternatives is Acetaminophen. It suppresses stomach pain. Anyhow, it does not help in inflammatory pain.
  • Proton pump inhibitors decrease the gastric release and are also beneficial against stomach pain related to gastritis or ulcers.
  • Prokinetics like domperidone is a safe NSAID alternative. It increases GI motility and helps relieve stomach pain.

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